Papers
Showing 174 published or preprint papers authored by the Bennett Institute.
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Impact of the COVID-19 pandemic on antipsychotic prescribing in individuals with autism, dementia, learning disability, serious mental illness or living in a care home
We describe the impact of the the COVID-19 pandemic on antipsychotic prescribing in those with autism, dementia, learning disability, serious mental illness or living in a care home.
Status: Published
Categories
- OpenSAFELY
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Challenges in Estimating the Effectiveness of 2 Doses of COVID-19 Vaccine Beyond 6 Months in England
This paper discusses the challenges in estimating long-term (>6 months) vaccine effectiveness in observational data, primarily due to high uptake of a subsequent third vaccine dose.
Status: Published
Categories
- OpenSAFELY
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Gout incidence and management during the COVID-19 pandemic in England, UK
Assessing how the COVID-19 pandemic impacted incidence and quality of care for people with gout in England, UK.
Status: Published
Categories
- OpenSAFELY
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Healthcare in England was affected by the COVID-19 pandemic across the pancreatic cancer pathway
The pandemic affected healthcare in England across the pancreatic cancer pathway. Positive lessons could be learnt from the services that were resilient and those that recovered quickly
Status: Published
Categories
- OpenSAFELY
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Living alone and mental health: parallel analyses in UK longitudinal population surveys and electronic health records prior to and during the COVID-19 pandemic
People living alone have poorer mental health and lower life satisfaction. During the pandemic, this gap in self-reported distress remained; however, there was a narrowing of the gap in service use.
Status: Published
Categories
- OpenSAFELY
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Eleven key measures for monitoring general practice clinical activity during COVID-19
This paper presents an important effort to develop an open-source software framework for monitoring trends and variations in healthcare over time in England. They demonstrate a compelling example of how this system can track key healthcare indicators over the course of the COVID-19 pandemic.
Status: Published
Categories
- OpenSAFELY
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Evaluation of the impact of COVID-19 pandemic on hospital admission related to common infections
We studied the changes in hospital admission rates for common infections during the Covid-19 pandemic, for those having and having not received antibiotic prescriptions in primary care
Status: Published
Categories
- OpenSAFELY
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Repeated antibiotic exposure and risk of hospitalisation and death following COVID-19 infection
We examined whether prior frequent antibiotic exposure is associated with severe COVID-19 outcomes.
Status: Published
Categories
- OpenSAFELY
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Ethnic differences in the indirect effects of the COVID-19 pandemic on clinical monitoring and hospitalisations for non-COVID conditions in England
We aimed to describe the impact of pandemic-related disruption on ethnic differences in clinical monitoring and hospital admissions for non-COVID conditions in England.
Status: Published
Categories
- OpenSAFELY
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Patient Characteristics Associated with Repeat Antibiotic Prescribing Pre- and during the COVID-19 Pandemic
With the approval of NHS England, we conducted a retrospective cohort study of >19 million English primary care patient records using the OpenSAFELY-TPP analytics platform. We analysed repeat/non-repeat prescribing frequency in monthly patient cohorts between January 2020 and 2022.
Status: Published
Categories
- OpenSAFELY
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A National Audit of Pancreatic Enzyme Prescribing in Pancreatic Cancer from 2015 to 2023 in England
Investigating the impact of the COVID-19 pandemic on PERT prescribing to people with unresectable pancreatic cancer and to investigate the national and regional rates from January 2015 to January 2023.
Status: Published
Categories
- OpenSAFELY
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Changes in medication safety indicators in England throughout the covid-19 pandemic using OpenSAFELY
This study aimed to implement complex, PINCER (pharmacist led information technology intervention) prescribing indicators, on a national scale with general practice data to describe the impact of the covid-19 pandemic on safe prescribing.
Status: Published
Categories
- OpenSAFELY
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Effectiveness of Sotrovimab and Molnupiravir in community settings in England across the Omicron BA.1 and BA.2 sublineages
We used the OpenSAFELY platform to emulate target trials to estimate the effectiveness of sotrovimab or molnupiravir, versus no treatment.
Status: Preprint
Categories
- OpenSAFELY
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Impact of COVID-19 on broad-spectrum antibiotic prescribing for common infections in primary care in England
The COVID-19 pandemic impacted the healthcare systems, adding extra pressure to reduce antimicrobial resistance. Therefore, we aimed to evaluate changes in antibiotic prescription patterns after COVID-19 started.
Status: Published
Categories
- OpenSAFELY
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The impact of COVID-19 on antibiotic prescribing in primary care in England
This study predicted risk factors for potentially inappropriate prescribing in primary care and how this changed during the Covid-19 pandemic
Status: Published
Categories
- OpenSAFELY
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Challenges in Estimating the Effectiveness of COVID-19 Vaccination Using Observational Data
This paper discusses the challenges in estimating vaccine effectiveness using observational data, and describes two approaches that help to overcome these challenges.
Status: Published
Categories
- OpenSAFELY
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Changes in COVID-19-related mortality across key demographic and clinical subgroups in England from 2020 to 2022
This study aimed to describe the burden of COVID-19-related mortality in population subgroups and how this has changed over successive waves of the pandemic, and report trends in absolute and relative COVID-19-related mortality risks across clinical and demographic population subgroups from 2020 to 2022.
Status: Published
Categories
- OpenSAFELY
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Data-Driven Identification of Unusual Prescribing Behavior: Analysis and Use of an Interactive Data Tool Using 6 Months of Primary Care Data From 6500 Practices in England
Data-driven approaches have the potential to overcome existing biases with regard to the planning and execution of audits, interventions, and policy making within NHS organizations, potentially revealing new targets for improved health care service delivery.
Status: Published
Categories
- OpenPrescribing